{"id":15450,"date":"2024-01-04T16:07:46","date_gmt":"2024-01-04T08:07:46","guid":{"rendered":"https:\/\/yilingcn88-prod.cn.siluzan.com\/?p=15450"},"modified":"2024-01-04T16:07:46","modified_gmt":"2024-01-04T08:07:46","slug":"2023%e5%b9%b4%e5%ba%a6%e5%b7%a8%e7%8c%ae%ef%bc%9a%e4%b8%ad%e5%9b%bd%e4%b8%ad%e8%8d%af%e9%a2%86%e5%9f%9f%e5%8d%81%e5%a4%a7%e5%8c%bb%e5%ad%a6%e7%a0%94%e7%a9%b6%e5%87%ba%e7%82%89","status":"publish","type":"post","link":"https:\/\/www.mtrty.com\/2023%e5%b9%b4%e5%ba%a6%e5%b7%a8%e7%8c%ae%ef%bc%9a%e4%b8%ad%e5%9b%bd%e4%b8%ad%e8%8d%af%e9%a2%86%e5%9f%9f%e5%8d%81%e5%a4%a7%e5%8c%bb%e5%ad%a6%e7%a0%94%e7%a9%b6%e5%87%ba%e7%82%89\/","title":{"rendered":"2023\u5e74\u5ea6\u5de8\u732e\uff1a\u4e2d\u56fd\u4e2d\u836f\u9886\u57df\u5341\u5927\u533b\u5b66\u7814\u7a76\u51fa\u7089"},"content":{"rendered":"

2023\u5e74\u5ea6\u5de8\u732e\uff1a\u4e2d\u56fd\u4e2d\u836f\u9886\u57df\u5341\u5927\u533b\u5b66\u7814\u7a76\u51fa\u7089\u533b\u5b66\u4e0d\u65ad\u5411\u524d\u53d1\u5c55\uff0c2023\u5e74\u4e5f\u4e0d\u4f8b\u5916\u3002\u56de\u987e\u8fd9\u4e00\u5e74\uff0c\u6211\u56fd\u79d1\u5b66\u5bb6\u5728\u4e2d\u836f\u9886\u57df\u53d6\u5f97\u4e86\u4e30\u7855\u7684\u7814\u7a76\u6210\u679c\uff0c\u4e3a\u4e16\u754c\u533b\u5b66\u7684\u53d1\u5c55\u505a\u51fa\u4e86\u5de8\u5927\u7684\u8d21\u732e\u3002<\/p>\n

\u2014 01 \u2014<\/strong><\/p>\n

JAMA\uff1a\u6768\u8dc3\u8fdb\u6559\u6388\u56e2\u961f\u7814\u7a76\u83b7\u91cd\u5927\u7a81\u7834\uff0c\u901a\u5fc3\u7edc\u80f6\u56ca\u663e\u8457\u964d\u4f4e\u6025\u6027\u5fc3\u6897\u60a3\u8005\u6b7b\u4ea1\u7387<\/strong><\/p>\n

doi: 10.1001\/jama.2023.19524.<\/p>\n

\u5fc3\u808c\u6897\u6b7b\u662f\u5168\u7403\u8303\u56f4\u5185\u81f4\u6b7b\u548c\u81f4\u6b8b\u7684\u4e3b\u8981\u75be\u75c5\u4e4b\u4e00\u3002STEMI\u60a3\u8005\u5c3d\u7ba1\u63a5\u53d7\u518d\u704c\u6ce8\u548c\u6700\u4f73\u836f\u7269\u6cbb\u7597\uff0c\u4ecd\u9762\u4e34\u8f83\u9ad8\u7684\u9662\u5185\u6b7b\u4ea1\u7387\u3001\u5fc3\u808c\u65e0\u590d\u6d41\u548c\u518d\u704c\u6ce8\u635f\u4f24\u98ce\u9669\u3002\u76ee\u524d\u5728\u5168\u7403\u8303\u56f4\u5185\uff0c\u4ecd\u7f3a\u4e4f\u7279\u5f02\u6027\u6cbb\u7597\u836f\u7269\u6765\u9632\u6cbb\u8fd9\u4e9b\u95ee\u9898\uff0c\u4e34\u5e8a\u4e9f\u9700\u65b0\u7684\u836f\u7269\u6216\u65b0\u7684\u6cbb\u7597\u7b56\u7565\u6539\u5584STEMI\u60a3\u8005\u6cbb\u7597\u73b0\u72b6\u3002<\/p>\n

\u901a\u5fc3\u7edc\u80f6\u56ca\u662f\u5728\u4e2d\u56fd\u5e94\u7528\u5e7f\u6cdb\u3001\u6cbb\u7597\u5fc3\u8111\u8840\u7ba1\u75be\u75c5\u7684\u4ee3\u8868\u6027\u836f\u7269\u3002\u7531\u4e2d\u56fd\u533b\u5b66\u79d1\u5b66\u9662\u961c\u5916\u533b\u9662\u6768\u8dc3\u8fdb\u6559\u6388\u7275\u5934\u5f00\u5c55\u4e86\u201c\u4e2d\u56fd\u901a\u5fc3\u7edc\u6cbb\u7597\u6025\u6027\u5fc3\u808c\u6897\u6b7b\u5fc3\u808c\u4fdd\u62a4\u7814\u7a76\uff08CTS-AMI\uff09\u201d\uff0c\u8fdb\u4e00\u6b65\u5728\u5927\u89c4\u6a21\u5fc3\u808c\u6897\u6b7b\u4eba\u7fa4\u4e2d\u8bc1\u5b9e\u5176\u6539\u5584ST\u6bb5\u62ac\u9ad8\u578b\u5fc3\u808c\u6897\u6b7b\uff08STEMI\uff09\u60a3\u8005\u4e34\u5e8a\u7ed3\u5c40\u7684\u80fd\u529b\u3002<\/p>\n

CTS-AMI\u7814\u7a76\u662f\u4e00\u9879\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5171\u7eb3\u5165\u4e2d\u56fd\u5927\u9646124\u5bb6\u533b\u9662\u3001\u53d1\u75c5\u65f6\u95f4\u572824\u5c0f\u65f6\u4ee5\u5185\u7684STEMI\u60a3\u8005\u3002\u7ed3\u679c\u663e\u793a\uff0c\u5728STEMI\u6307\u5357\u63a8\u8350\u7684\u6cbb\u7597\u57fa\u7840\u4e0a\uff0c\u52a0\u7528\u901a\u5fc3\u7edc\u80f6\u56ca\u53ef\u4ee5\u663e\u8457\u6539\u5584\u4e2d\u56fdSTEMI\u60a3\u800530\u5929\u548c1\u5e74\u7684\u4e34\u5e8a\u9884\u540e\uff0c\u7279\u522b\u662f\u5728\u964d\u4f4e\u5fc3\u6e90\u6027\u6b7b\u4ea1\u548c\u4e25\u91cd\u5e76\u53d1\u75c7\u65b9\u9762\u7597\u6548\u663e\u8457\uff0c\u800c\u4e14\u5e76\u4e0d\u589e\u52a0\u5927\u51fa\u8840\u7b49\u4e25\u91cd\u4e0d\u826f\u53cd\u5e94\u7684\u98ce\u9669\u3002CTS-AMI\u7814\u7a76\u7ed3\u679c\u652f\u6301\u901a\u5fc3\u7edc\u80f6\u56ca\u81f3\u5c11\u5728\u4e2d\u56fd\u6216\u5176\u4ed6\u53d1\u5c55\u4e2d\u56fd\u5bb6\uff0c\u53ef\u4ee5\u4f5c\u4e3aSTEMI\u60a3\u8005\u7684\u836f\u7269\u6cbb\u7597\u9009\u62e9\u3002\u671f\u5f85\u672a\u6765\u901a\u5fc3\u7edc\u80f6\u56ca\u53ef\u4ee5\u8fdb\u4e00\u6b65\u5f00\u5c55\u76f8\u5173\u7814\u7a76\uff0c\u660e\u786e\u5176\u5728STEMI\u60a3\u8005\u4e2d\u7597\u6548\u7684\u4f5c\u7528\u673a\u5236\u3002<\/p>\n

\u53d1\u8868\u671f\u520a\uff1a<\/strong>JAMA. 2023 Oct 24;330(16):1534-1545.<\/p>\n

\u901a\u8baf\u4f5c\u8005\/\u5173\u952e\u4f5c\u8005\uff1a<\/strong>Yuejin Yang, Xiangdong Li<\/p>\n

\u4e3b\u8981\u4f5c\u8005\u5355\u4f4d\uff1a<\/strong>\u4e2d\u56fd\u533b\u5b66\u79d1\u5b66\u9662\u961c\u5916\u533b\u9662\uff1b\u56fd\u5bb6\u5fc3\u8840\u7ba1\u75c5\u4e2d\u5fc3<\/p>\n

\u201402\u2014<\/strong><\/p>\n

Virol J\uff1a\u949f\u5357\u5c71\u9662\u58eb\u56e2\u961f\u6700\u65b0\u7814\u7a76\u518d\u6b21\u8bc1\u660e\u8fde\u82b1\u6e05\u761f\u6cbb\u7597\u65b0\u51a0\u80ba\u708e\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027<\/strong><\/p>\n

doi: 10.1186\/s12985-023-02144-6.<\/p>\n

\u8fde\u82b1\u6e05\u761f\u5c5e\u4e8e\u4e2d\u6210\u836f\uff0c\u5176\u4e3b\u8981\u6210\u5206\u5305\u62ec\u8fde\u7fd8\u3001\u91d1\u94f6\u82b1\u3001\u7099\u9ebb\u9ec4\u3001\u7092\u82e6\u674f\u4ec1\u3001\u77f3\u818f\u3001\u677f\u84dd\u6839\u7b49\u7b49\uff0c\u8be5\u836f\u591a\u7528\u4e8e\u6cbb\u7597\u6d41\u884c\u6027\u611f\u5192\u3002\u300a\u65b0\u578b\u51a0\u72b6\u75c5\u6bd2\u80ba\u708e\u8bca\u65ad\u65b9\u6848\uff08\u8bd5\u884c\u7b2c\u4e5d\u7248\uff09\u300b\u4e2d\u66fe\u660e\u786e\u63a8\u8350\u8fde\u82b1\u6e05\u761f\u9897\u7c92\uff08\u80f6\u56ca\uff09\u7528\u4e8e\u533b\u5b66\u89c2\u5bdf\u671f\u548c\u8f7b\u75c7\u3001\u666e\u901a\u578b\u60a3\u8005\u7684\u63a8\u8350\u7528\u836f\u3002<\/p>\n

\u6765\u81ea\u5e7f\u5dde\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u7b2c\u4e00\u533b\u9662\u56fd\u5bb6\u547c\u5438\u7cfb\u7edf\u75be\u75c5\u4e34\u5e8a\u533b\u5b66\u7814\u7a76\u4e2d\u5fc3\u949f\u5357\u5c71\u9662\u58eb\u7387\u9886\u5176\u56e2\u961f\u5728Virol J\u4e0a\u6700\u65b0\u53d1\u8868\u6587\u7ae0\uff0c\u6b64\u6b21\u6539\u4e3a\u91c7\u7528\u591a\u4e2d\u5fc3\u3001\u53cc\u76f2\u3001\u968f\u673a\u5bf9\u7167\u7814\u7a76\uff0c\u518d\u6b21\u8bc1\u660e\u4e86\u8fde\u82b1\u6e05\u761f\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\uff0c\u63d0\u9ad8\u4e86\u4e34\u5e8a\u8bc1\u636e\u7684\u6c34\u5e73\u3002\u7ed3\u679c\u663e\u793a\uff0c\u8fde\u82b1\u6e05\u761f\u7684\u6cbb\u7597\u663e\u8457\u7f29\u77ed\u4e86\u60a3\u8005\u7684\u65b0\u51a0\u75c7\u72b6\u6539\u5584\u6216\u7f13\u89e3\u7684\u4e2d\u4f4d\u65f6\u95f4\uff0c\u7f29\u77ed\u81f34\u5929\u5de6\u53f3\u3002\u5355\u4e2a\u5177\u4f53\u75c7\u72b6\u6765\u8bf4\uff0c\u5728\u8fde\u82b1\u6e05\u761f\u7684\u6cbb\u7597\u4e0b\uff0c\u9f3b\u585e\/\u6d41\u9f3b\u6d95\u7684\u75c7\u72b6\u6301\u7eed\u4e2d\u4f4d\u65f6\u95f4\u88ab\u7f29\u77ed\u81f32.8\u5929\uff08\u5bf9\u7167\u7ec43.7\u5929\uff09\uff0c\u5589\u5499\u75db2.0\u5929\uff08vs 2.6\u5929\uff09\u3001\u54b3\u55fd3.2\u5929\uff08vs 4.9\u5929\uff09\u3001\u53d1\u70ed1.0\u5929\uff08vs 1.3\u5929\uff09\u3001\u65e0\u529b\/\u6613\u75b2\u52b31.3\u5929\uff08vs 1.9\u5929\uff09\u548c\u808c\u8089\u75bc\u75db1.5\u5929\uff08vs 2.0\u5929\uff09\u3002\u4f46\u6c14\u77ed\u3001\u5934\u75db\u3001\u53d1\u51b7\/\u5bd2\u6218\u5219\u6ca1\u6709\u663e\u8457\u5dee\u5f02\u3002<\/p>\n

\u603b\u4e4b\uff0c\u8fd9\u9879\u91c7\u7528\u4e86\u53cc\u76f2\u7684\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\u8bc1\u5b9e\uff0c\u8fde\u82b1\u6e05\u761f\u80f6\u56ca\u5728\u8f7b\u81f3\u4e2d\u5ea6\u65b0\u51a0\u80ba\u708e\u60a3\u8005\u4e2d\u5177\u6709\u8f83\u597d\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u2014\u2014\u572814\u5929\u7684\u8fde\u82b1\u6e05\u761f\u6cbb\u7597\u663e\u8457\u7f29\u77ed\u4e86\u4e3b\u8981\u75c7\u72b6\u7684\u7f13\u89e3\u65f6\u95f4\u4ee5\u53ca\u56de\u590d\u7387\uff0c\u80fd\u591f\u52a0\u901f\u7edd\u5927\u591a\u6570\u65b0\u51a0\u75c7\u72b6\u7684\u6062\u590d\uff1b\u540c\u65f6\uff0c\u4e5f\u6709\u7740\u548c\u5b89\u6170\u5242\u76f8\u8fd1\u7684\u5b89\u5168\u6027\u3002<\/p>\n

\u53d1\u8868\u671f\u520a\uff1a<\/strong>Virol J. 2023 Nov 28;20(1):277.<\/p>\n

\u901a\u8baf\u4f5c\u8005\/\u5173\u952e\u4f5c\u8005\uff1a<\/strong>Nan-Shan Zhong\uff0c Wei-Jie Guan<\/p>\n

\u4e3b\u8981\u4f5c\u8005\u5355\u4f4d\uff1a<\/strong>\u5e7f\u5dde\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u7b2c\u4e00\u533b\u9662\u56fd\u5bb6\u547c\u5438\u7cfb\u7edf\u75be\u75c5\u4e34\u5e8a\u533b\u5b66\u7814\u7a76\u4e2d\u5fc3\uff1b\u547c\u5438\u75be\u75c5\u5168\u56fd\u91cd\u70b9\u5b9e\u9a8c\u5ba4<\/p>\n

\u201403\u2014<\/strong><\/p>\n

Nature\u5b50\u520a\uff1a\u674e\u540e\u5f00\u6559\u6388\u7b49\u56e2\u961f\u63ed\u793a\u732a\u53bb\u6c27\u80c6\u9178\u6cbb\u7597\u975e\u9152\u7cbe\u6027\u8102\u80aa\u809d\u7684\u65b0\u673a\u5236<\/strong><\/p>\n

doi: 10.1038\/s41467-023-41061-8.<\/p>\n

\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u75c5\uff08NAFLD\uff09\u901a\u5e38\u4ee5\u80c6\u6c41\u9178\uff08BA\uff09\u7a33\u6001\u7834\u574f\u4e3a\u7279\u5f81\u3002\u7136\u800c\uff0c\u67d0\u4e9bBA\u5728NAFLD\u4e2d\u7684\u786e\u5207\u4f5c\u7528\u77e5\u4e4b\u751a\u5c11\u3002<\/p>\n

\u6765\u81ea\u4e0a\u6d77\u4e2d\u533b\u836f\u5927\u5b66\u674e\u540e\u5f00\u6559\u6388\u53ca\u4e2d\u56fd\u79d1\u5b66\u9662\u4e0a\u6d77\u836f\u7269\u7814\u7a76\u6240\u8c22\u5c91\u6559\u6388\u5171\u540c\u901a\u8baf\u5728Nature Communications \u53d1\u8868\u4e86\u4e00\u9879\u7814\u7a76\uff0c\u8be5\u7814\u7a76\u89c2\u5bdf\u5230NAFLD\u60a3\u8005\u7684\u8840\u6e05HDCA\u6c34\u5e73\u4f4e\u4e8e\u5065\u5eb7\u53d7\u8bd5\u8005\uff0c\u8fd9\u4e0eNAFLD\u4e25\u91cd\u7a0b\u5ea6\u5448\u8d1f\u76f8\u5173\uff0c\u5e76\u4e14NAFLD\u5c0f\u9f20\u7684\u809d\u810f\u548c\u80a0\u9053\u542b\u91cf\u6301\u7eed\u964d\u4f4e\u3002HDCA\u901a\u8fc7\u4fc3\u8fdbPPAR\u03b1\u7684\u6838\u5185\u5b9a\u4f4d\uff0c\u5bfc\u81f4\u809d\u810f\u8102\u80aa\u9178\u6c27\u5316\u589e\u5f3a\uff0c\u4ece\u800c\u51cf\u8f7b\u5c0f\u9f20NAFLD\u3002<\/p>\n

\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0cHDCA\u7684\u6297NAFLD\u4f5c\u7528\u5728\u6574\u4f53\u548c\u809d\u7ec6\u80de\u7279\u5f02\u6027PPAR\u03b1\u6572\u9664\u5c0f\u9f20\u4e2d\u88ab\u6d88\u9664\u3002HDCA\u901a\u8fc7\u4e0eRAN\u86cb\u767d\u76f4\u63a5\u7ed3\u5408\uff0c\u963b\u788d\u4e86RAN\/CRM1\/PPAR\u03b1\u8f93\u51fa\u5f02\u6e90\u4e09\u805a\u4f53\u7684\u5f62\u6210\uff0c\u5bfc\u81f4\u6838\u5185PPAR\u03b1\u7684\u79ef\u7d2f\u3002HDCA\u662f\u4e00\u79cd\u6709\u524d\u666f\u7684NAFLD\u6cbb\u7597\u836f\u7269\uff0c\u5e76\u901a\u8fc7\u9776\u5411PPAR\u03b1\u7a7f\u68ad\u673a\u5236\u4e3aNAFLD\u63d0\u4f9b\u4e86\u4e00\u79cd\u6cbb\u7597\u7b56\u7565\u3002<\/p>\n

\u53d1\u8868\u671f\u520a\uff1a<\/strong>Nat Commun. 2023 Sep 6;14(1):5451.<\/p>\n

\u901a\u8baf\u4f5c\u8005\/\u5173\u952e\u4f5c\u8005\uff1a<\/strong>Houkai Li \uff0cLili Sheng<\/p>\n

\u4e3b\u8981\u4f5c\u8005\u5355\u4f4d\uff1a<\/strong>\u4e0a\u6d77\u4e2d\u533b\u836f\u5927\u5b66\u4e2d\u836f\u5b66\u9662\uff1b\u4e2d\u56fd\u79d1\u5b66\u9662\u4e0a\u6d77\u836f\u7269\u7814\u7a76\u6240<\/p>\n

\u201404\u2014<\/strong><\/p>\n

STTT\uff1a\u9648\u8bed\u8c26\u6559\u6388\u56e2\u961f\u53d1\u8868\u4e16\u754c\u6700\u5927\u7684\u4e2d\u533b\u836f\u6570\u636e\u5e93\uff0c\u5e76\u63d0\u4f9b\u57fa\u4e8e\u6df1\u5ea6\u5b66\u4e60\u7684\u4e2d\u897f\u836f\u4e0d\u826f\u53cd\u5e94\u9884\u6d4b\u7b97\u6cd5<\/strong><\/p>\n

doi: 10.1038\/s41392-023-01339-1.<\/p>\n

\u4e2d\u533b\u836f\u5728\u4e2d\u56fd\u5df2\u7ecf\u5e7f\u6cdb\u4f7f\u7528\u4e86\u5343\u5e74\uff0c\u5728\u6539\u5584\u5065\u5eb7\u4ee5\u53ca\u9884\u9632\u548c\u6cbb\u7597\u5404\u79cd\u75be\u75c5\u4e2d\u5df2\u7ecf\u663e\u793a\u51fa\u4e86\u5de8\u5927\u6f5c\u529b\u3002\u4e2d\u533b\u836f\u73b0\u4ee3\u5316\u7684\u4e24\u4e2a\u5173\u952e\u65b9\u9762\u662f\u786e\u5b9a\u4e2d\u836f\u7684\u6709\u6548\u6210\u5206\u548c\u9610\u660e\u6709\u6548\u6210\u5206\u4e0e\u9776\u70b9\u4e4b\u95f4\u7684\u4f5c\u7528\u673a\u5236\u3002\u56e0\u6b64\uff0c\u5efa\u8bbe\u4e00\u4e2a\u5168\u9762\u3001\u9ad8\u53ef\u9760\u6027\u7684\u4e2d\u533b\u6570\u636e\u5e93\u662f\u5341\u5206\u5fc5\u8981\u7684\u3002<\/p>\n

\u6765\u81ea\u4e2d\u5c71\u5927\u5b66\u667a\u80fd\u5de5\u7a0b\u5b66\u9662\u9648\u8bed\u8c26\u6559\u6388\u56e2\u961f\u5728Signal Transduction and Targeted Therapy\u6742\u5fd7\u4e0a\u53d1\u8868\u4e86\u4e00\u9879\u7814\u7a76\uff0c\u8be5\u7814\u7a76\u5efa\u7acb\u4e16\u754c\u6700\u5927\u7684\u4e2d\u533b\u836f\u6570\u636e\u5e93TCMBank\uff0c\u63d0\u4f9b\u4e869192\u79cd\u8349\u836f\uff0c61,966\u79cd\u6210\u5206\uff0c15,179\u4e2a\u9776\u6807\uff0c32,529\u79cd\u75be\u75c5\u3002<\/p>\n

\u9664\u6b64\u4e4b\u5916\uff0c\u7814\u7a76\u8005\u9488\u5bf9\u4e2d\u897f\u836f\u4e4b\u95f4\u53ef\u80fd\u53d1\u751f\u7684\u4e0d\u826f\u53cd\u5e94\uff0c\u8bbe\u8ba1\u4e86\u4e00\u4e2a\u65b0\u9896\u7b97\u6cd5\u7684\u6280\u672f\u3002\u7814\u7a76\u8005\u5728\u4e24\u4e2a\u73b0\u5b9e\u4e16\u754c\u7684\u516c\u5171\u836f\u7269\u76f8\u4e92\u4f5c\u7528\uff08DDI\uff09\u6570\u636e\u96c6\u4e0a\u63d0\u51fa\u4e86\u4e24\u4e2a\u6a21\u578b\uff0c3DGT-DDI\u548c SA-DDI, \u6765\u9884\u6d4b\u4e24\u79cd\u836f\u7269\u5316\u5408\u7269\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u3002\u7ecf\u8fc7\u6570\u636e\u96c6\u7684\u5b9e\u9a8c\u5df2\u7ecf\u8bc1\u660e\u4e863DGT-DDI \u548c SA-DDI \u5728\u4e24\u4e2a\u516c\u5171 DDI \u6570\u636e\u96c6\u4e0a\u5b9e\u73b0\u4e86\u6700\u7cbe\u786e\u7684\u9884\u6d4b\u6027\u80fd\u3002<\/p>\n

\u53d1\u8868\u671f\u520a\uff1a<\/strong>Signal Transduct Target Ther. 2023 Mar 31;8(1):127.<\/p>\n

\u901a\u8baf\u4f5c\u8005\/\u5173\u952e\u4f5c\u8005\uff1a<\/strong>Calvin Yu-Chian Chen\uff0cQiujie Lv<\/p>\n

\u4e3b\u8981\u4f5c\u8005\u5355\u4f4d\uff1a<\/strong>\u4e2d\u5c71\u5927\u5b66\u667a\u80fd\u5de5\u7a0b\u5b66\u9662<\/p>\n

\u201405\u2014<\/strong><\/p>\n

STTT\uff1a\u5f20\u536b\u4e1c\u6559\u6388\u56e2\u961f\u63ed\u793a\u9ec4\u82aa\u7532\u82f7\u884d\u751f\u7269\u6cbb\u7597\u6897\u6b7b\u540e\u5fc3\u8870\u7684\u4f5c\u7528\u548c\u673a\u5236<\/strong><\/p>\n

doi: 10.1038\/s41392-023-01660-9.<\/p>\n

\u9ec4\u82aa\u7532\u82f7\uff08Astragaloside IV\uff09\u662f\u4f20\u7edf\u6cbb\u7597\u5fc3\u8870\u4e2d\u836f\u9ec4\u82aa\u7684\u6709\u6548\u6d3b\u6027\u7269\u8d28\u3002\u7814\u7a76\u8868\u660e\uff0cAstragaloside IV\u80fd\u663e\u8457\u9006\u8f6c\u5b9e\u9a8c\u6027\u6162\u6027\u5fc3\u8870\u6a21\u578b\u7684\u4e0d\u826f\u91cd\u6784\uff0c\u4f46\u76f4\u63a5\u9776\u70b9\u548c\u4f5c\u7528\u673a\u5236\u4e0d\u660e\u786e\u3002<\/p>\n

\u6765\u81ea\u4e2d\u56fd\u534f\u548c\u533b\u79d1\u5927\u5b66\u836f\u7528\u690d\u7269\u7814\u7a76\u6240\u5f20\u536b\u4e1c\u6559\u6388\u5728Signal Transduction and Targeted Therapy\u6742\u5fd7\u4e0a\u53d1\u8868\u4e86\u4e00\u9879\u7814\u7a76\uff0c\u6df1\u5165\u9610\u660e\u4e86\u65b0\u5206\u5b50\u9ec4\u82aa\u7532\u82f7\u884d\u751f\u7269HHQ16\u6cbb\u7597\u6897\u6b7b\u540e\u5fc3\u529b\u8870\u7aed\u7684\u4f5c\u7528\u548c\u673a\u5236\u3002\u5f20\u536b\u4e1c\u6559\u6388\u3001\u5218\u971e\u6559\u6388\u53ca\u897f\u5357\u533b\u79d1\u5927\u5b66\u6bb5\u5927\u8dc3\u6559\u6388\u4e3a\u672c\u8bba\u6587\u7684\u5171\u540c\u901a\u8baf\u4f5c\u8005\uff0c\u6d77\u519b\u519b\u533b\u5927\u5b66\u836f\u5b66\u9662\u4e3a\u7b2c\u4e00\u5355\u4f4d\u3002<\/p>\n

\u8be5\u7814\u7a76\u4ee5Astragaloside IV\u4e3a\u5148\u5bfc\u5316\u5408\u7269\uff0c\u7b5b\u9009\u51fa\u4e86\u65b0\u7684\u5c0f\u5206\u5b50HHQ16\uff0c\u5176\u901a\u8fc7\u7279\u5f02\u6027\u7ed3\u5408\u9776\u5411\u964d\u89e3lnc4012\/9456\uff0c\u6291\u5236\u4e86\u5fc3\u808c\u6897\u6b7b\u8bf1\u5bfc\u7684\u75c5\u7406\u5e94\u6fc0\u4e0blnc4012\/9456\u7684\u9ad8\u8868\u8fbe\uff0c\u8fdb\u800c\u51cf\u5f31G3BP2\u4e0eI\u03baB\u03b1\u7684\u7ed3\u5408\uff0c\u6291\u5236NF-\u03baB p65\u6838\u8f6c\u4f4d\uff0c\u4ece\u800c\u6709\u6548\u9006\u8f6c\u5fc3\u808c\u6897\u6b7b\u8bf1\u5bfc\u7684\u80a5\u5927\u548c\u5fc3\u8870\u3002<\/p>\n

\u53d1\u8868\u671f\u520a\uff1a<\/strong>Signal Transduct Target Ther. 2023 Oct 19;8(1):414.<\/p>\n

\u901a\u8baf\u4f5c\u8005\/\u5173\u952e\u4f5c\u8005\uff1a<\/strong>Xia Liu\uff0cWeidong Zhang<\/p>\n

\u4e3b\u8981\u4f5c\u8005\u5355\u4f4d\uff1a<\/strong>\u4e2d\u56fd\u533b\u5b66\u79d1\u5b66\u9662\uff1b\u4e2d\u56fd\u534f\u548c\u533b\u79d1\u5927\u5b66\u836f\u7528\u690d\u7269\u7814\u7a76\u6240<\/p>\n

\u201406\u2014<\/strong><\/p>\n

Science\u5b50\u520a\uff1a\u5468\u96ea\u5fe0\u6559\u6388\u7b49\u56e2\u961f\u63d0\u51fa\u7f51\u7edc\u533b\u5b66\u7406\u8bba\uff0c\u4e3a\u4e2d\u533b\u836f\u5efa\u7acb\u79d1\u5b66\u57fa\u7840<\/strong><\/p>\n

doi: 10.1126\/sciadv.adh0215.<\/p>\n

\u4e2d\u56fd\u4f20\u7edf\u533b\u5b66\u662f\u4e00\u79cd\u4e2a\u6027\u5316\u548c\u6574\u4f53\u7684\u6cbb\u7597\u65b9\u6cd5\uff0c\u4f7f\u7528\u9488\u5bf9\u60a3\u8005\u75c7\u72b6\u7684\u5929\u7136\u533b\u7597\u4ea7\u54c1\u6cbb\u7597\u75be\u75c5\uff0c\u63d0\u4f9b\u4e86\u4e30\u5bcc\u7684\u6cbb\u7597\u5019\u9009\u836f\u7269\u5e93\u3002\u7136\u800c\uff0c\u5c3d\u7ba1\u4e34\u5e8a\u6570\u636e\u548c\u5355\u4e00\u4e2d\u8349\u836f\/\u5904\u65b9\u7684\u7814\u7a76\u8868\u660e\u67d0\u4e9b\u4e2d\u8349\u836f\u6cbb\u7597\u662f\u6709\u6548\u7684\uff0c\u4f46\u4e2d\u533b\u5b66\u5982\u4f55\u9009\u62e9\u4e2d\u8349\u836f\u6cbb\u7597\u75be\u75c5\u7684\u4e00\u822c\u673a\u5236\u4ecd\u7136\u672a\u77e5\u3002<\/p>\n

\u6765\u81ea\u5317\u4eac\u4ea4\u901a\u5927\u5b66\u8ba1\u7b97\u673a\u4e0e\u4fe1\u606f\u6280\u672f\u5b66\u9662\u5468\u96ea\u5fe0\u6559\u6388\u3001\u5357\u4eac\u4fe1\u606f\u5de5\u7a0b\u5927\u5b66\u4eba\u5de5\u667a\u80fd\u5b66\u9662\u7518\u6653\u535a\u58eb\u53ca\u7f8e\u56fd\u4e1c\u5317\u5927\u5b66 Albert-L\u00e1szl\u00f3 Barab\u00e1si \u6559\u6388\u7b49\u4eba\u5728Science Advances \u6742\u5fd7\u4e0a\u53d1\u8868\u4e86\u4e00\u9879\u7814\u7a76\uff0c\u8be5\u7814\u7a76\u5f00\u53d1\u4e86\u4e00\u79cd\u9884\u6d4b\u4e2d\u836f\u7597\u6548\u7684\u4e2d\u533b\u836f\u7f51\u7edc\u533b\u5b66\u7406\u8bba\uff0c\u53d1\u73b0\u4e2d\u836f\u201c\u8fa8\u8bc1\u8bba\u6cbb\u201d\u7684\u4f20\u7edf\u6cbb\u7597\u539f\u5219\u53ef\u4ee5\u901a\u8fc7\u4e2d\u836f\u4e0e\u75be\u75c5\u75c7\u72b6\u5728\u86cb\u767d\u8d28\u7f51\u7edc\u4e0a\u7684\u62d3\u6251\u90bb\u8fd1\u5173\u7cfb\u89e3\u91ca\uff0c\u5e76\u901a\u8fc7\u771f\u5b9e\u4e16\u754c\u4e34\u5e8a\u6570\u636e\u9a8c\u8bc1\uff0c\u9996\u6b21\u63a2\u7d22\u5efa\u7acb\u4e86\u89e3\u91ca\u4e2d\u836f\u6cbb\u7597\u7cfb\u7edf\u539f\u7406\u7684\u79d1\u5b66\u7406\u8bba\uff0c\u5e76\u7ed3\u5408\u771f\u5b9e\u4e16\u754c\u4e34\u5e8a\u6570\u636e\u8fdb\u884c\u4e86\u6709\u6548\u6027\u9a8c\u8bc1\u3002<\/p>\n

\u53d1\u8868\u671f\u520a\uff1a<\/strong>Sci Adv. 2023 Oct 27;9(43):eadh0215.<\/p>\n

\u901a\u8baf\u4f5c\u8005\/\u5173\u952e\u4f5c\u8005\uff1a<\/strong>Xuezhong Zhou\uff0cXiao Gan<\/p>\n

\u4e3b\u8981\u4f5c\u8005\u5355\u4f4d\uff1a<\/strong>\u5317\u4eac\u4ea4\u901a\u5927\u5b66\uff1b\u5357\u4eac\u4fe1\u606f\u5de5\u7a0b\u5927\u5b66<\/p>\n

\u201407\u2014<\/strong><\/p>\n

STTT\uff1a\u5f20\u8c6a\u6559\u6388\u7b49\u56e2\u961f\u53d1\u73b0\u96f7\u516c\u85e4\u7ea2\u7d20\u662f\u4e00\u79cd\u6709\u6548\u7684\u6f5c\u5728\u7684\u6cbb\u7597\u7ed3\u76f4\u80a0\u764c\u836f\u7269<\/strong><\/p>\n

doi: 10.1038\/s41392-022-01231-4.<\/p>\n

\u96f7\u516c\u85e4\u7ea2\u7d20\u662f\u4ece\u4f20\u7edf\u836f\u7269\u4e2d\u5206\u79bb\u51fa\u6765\u7684\u6700\u6709\u524d\u9014\u7684\u5929\u7136\u836f\u7528\u4ea7\u7269\u4e4b\uff0c\u5176\u836f\u7406\u6d3b\u6027\u88ab\u5e7f\u6cdb\u7814\u7a76\u3002\u8d8a\u6765\u8d8a\u591a\u7684\u8bc1\u636e\u8868\u660e\uff0c\u96f7\u516c\u85e4\u7ea2\u7d20\u8868\u73b0\u51fa\u6709\u6548\u7684\u6297\u80bf\u7624\u529f\u6548\u3002\u5728\u96f7\u516c\u85e4\u7ea2\u7d20\u5904\u7406\u7684\u5404\u79cd\u764c\u7ec6\u80de\u4e2d\uff0c\u7ecf\u5e38\u89c2\u5bdf\u5230\u7ec6\u80de\u51cb\u4ea1\u548c\u6d3b\u6027\u6c27\u7684\u8bf1\u5bfc\u3002<\/p>\n

\u6765\u81ea\u4e2d\u56fd\u79d1\u5b66\u9662\u4e0a\u6d77\u836f\u7269\u7814\u7a76\u6240\u5f20\u8c6a\u6559\u6388\uff0c\u4e0a\u6d77\u4ea4\u901a\u5927\u5b66\u5f20\u7ff1\u53ca\u5f90\u9896\u6559\u6388\u5171\u540c\u5728Signal Transduction and Targeted Therapy\u4e0a\u53d1\u8868\u4e86\u4e00\u9879\u7814\u7a76\u53d1\u73b0\u96f7\u516c\u85e4\u7ea2\u7d20\u901a\u8fc7\u5171\u4ef7\u9776\u5411\u8fc7\u6c27\u5316\u7269\u6c27\u5316\u8fd8\u539f\u86cb\u767d1\u6291\u5236\u7ed3\u76f4\u80a0\u764c\u3002\u8be5\u7814\u7a76\u5f00\u53d1\u4e86\u4e00\u4e2a\u57fa\u4e8e\u6587\u672c\u6316\u6398\u7684web\u670d\u52a1\u5668\u5de5\u5177\uff0c\u4ece\u6240\u67e5\u8be2\u5316\u5408\u7269\u7684\u7ec4\u5b66\u6570\u636e\u4e2d\u4e30\u5bcc\u76ee\u6807\u3002\u7ecf\u9274\u5b9a\uff0c\u8fc7\u6c27\u5316\u7269\u8fd8\u86cb\u767d1 (PRDX1)\u4e3a\u96f7\u516c\u85e4\u7ea2\u7d20\u5728\u7ed3\u76f4\u80a0\u764c\u4e2d\u7684ROS\u8c03\u63a7\u9776\u86cb\u767d\u3002\u8be5\u7814\u7a76\u89e3\u6790\u7684\u9ad8\u5206\u8fa8\u7387\u6676\u4f53\u7ed3\u6784\u63ed\u793a\u4e86\u96f7\u516c\u85e4\u7ea2\u7d20\u4e0ePRDX1\u72ec\u7279\u7684\u5171\u4ef7\u7ed3\u5408\u6a21\u5f0f\u3002<\/p>\n

\u5728\u6676\u4f53\u7ed3\u6784\u5206\u6790\u7684\u57fa\u7840\u4e0a\u5408\u6210\u4e86\u6297PRDX1\u6d3b\u6027\u589e\u5f3a\u3001\u5bf9PRDX2~PRDX6\u9009\u62e9\u6027\u589e\u5f3a\u7684\u65b0\u578b\u884d\u751f\u726919-048\u3002\u96f7\u516c\u85e4\u7ea2\u7d20\u548c19-048\u5747\u80fd\u6709\u6548\u6291\u5236\u7ed3\u76f4\u80a0\u764c\u7ec6\u80de\u589e\u6b96\u3002\u96f7\u516c\u85e4\u7ea2\u7d20\u548c19-048\u5bf9\u643a\u5e26PRDX1\u6572\u9664\u7ed3\u76f4\u80a0\u764c\u7ec6\u80de\u7684\u5f02\u79cd\u79fb\u690d\u88f8\u9f20\u7684\u6297\u80bf\u7624\u6548\u679c\u663e\u8457\u964d\u4f4e\u3002\u96f7\u516c\u85e4\u7ea2\u7d20\u621619-048\u5904\u7406\u540ep53\u4fe1\u53f7\u901a\u8def\u4e0b\u6e38\u591a\u4e2a\u57fa\u56e0\u663e\u8457\u4e0a\u8c03\u3002<\/p>\n

\u53d1\u8868\u671f\u520a\uff1a<\/strong>Signal Transduct Target Ther. 2023 Feb 3;8(1):51.<\/p>\n

\u901a\u8baf\u4f5c\u8005\/\u5173\u952e\u4f5c\u8005\uff1a<\/strong>Hao Zhang\uff0cYing Xu<\/p>\n

\u4e3b\u8981\u4f5c\u8005\u5355\u4f4d\uff1a<\/strong>\u4e2d\u56fd\u79d1\u5b66\u9662\u4e0a\u6d77\u836f\u7269\u7814\u7a76\u6240\uff1b\u4e0a\u6d77\u4ea4\u901a\u5927\u5b66<\/p>\n

\u201408\u2014<\/strong><\/p>\n

J Ethnopharmacol\uff1a\u5d14\u5143\u7490\u7814\u7a76\u5458\u9610\u8ff0\u4e86\u4e2d\u533b\u836f\u6cbb\u7597\u95f4\u8d28\u6027\u80ba\u75c5\u7684\u6f5c\u529b<\/strong><\/p>\n

doi: 10.1016\/j.jep.2023.116952.<\/p>\n

\u95f4\u8d28\u6027\u80ba\u75c5\uff08ILD\uff09\u662f\u4e00\u79cd\u9884\u540e\u4e0d\u826f\u3001\u96be\u4ee5\u5b8c\u5168\u5eb7\u590d\u7684\u6162\u6027\u80ba\u529f\u80fd\u969c\u788d\u75be\u75c5\u3002\u4e34\u5e8a\u4e0a\u4f7f\u7528\u7684\u6cbb\u7597\u6027\u836f\u7269\uff0c\u5982\u7cd6\u76ae\u8d28\u6fc0\u7d20\u548c\u514d\u75ab\u6291\u5236\u5242\u7b49\uff0c\u6cbb\u7597\u6548\u679c\u4e0d\u663e\u8457\u5e76\u4f34\u6709\u4e25\u91cd\u7684\u526f\u4f5c\u7528\u3002\u8fd1\u5e74\u6765\uff0c\u4f20\u7edf\u4e2d\u533b\u836f\u5728\u9884\u9632\u548c\u6cbb\u7597\u80ba\u90e8\u75be\u75c5\u7684\u63a2\u7d22\u548c\u5e94\u7528\u4e2d\u53d6\u5f97\u4e86\u5f88\u5927\u7684\u8fdb\u5c55\u3002<\/p>\n

\u6765\u81ea\u5929\u6d25\u4e2d\u533b\u836f\u5927\u5b66\u7ec4\u5206\u4e2d\u836f\u56fd\u5bb6\u91cd\u70b9\u5b9e\u9a8c\u5ba4\u7684\u5d14\u5143\u7490\u7814\u7a76\u5458\u53d1\u8868\u5728J Ethnopharmacol\u6742\u5fd7\u4e0a\u4e00\u9879\u7efc\u8ff0\uff0c\u5bf9\u4e2d\u533b\u836f\u7528\u4e8e\u6cbb\u7597\u95f4\u8d28\u6027\u80ba\u75c5\u7684\u5355\u4f53\u6210\u5206\u3001\u603b\u63d0\u53d6\u7269\u548c\u4f20\u7edf\u5904\u65b9\u8fdb\u884c\u7efc\u8ff0\uff0c\u5e76\u9610\u660e\u5176\u5206\u5b50\u673a\u5236\u4e3a\u5176\u6cbb\u7597ILD\u63d0\u4f9b\u53c2\u8003\u3002<\/p>\n

\u5177\u4f53\u800c\u8a00\uff0c\u751f\u7269\u78b1\u3001\u9ec4\u916e\u7c7b\u7b49\u4e2d\u836f\u5355\u4f53\u6d3b\u6027\u6210\u5206\u5bf9\u6cbb\u7597ILD\u5177\u6709\u6f5c\u5728\u7684\u4f18\u52bf\u3002\u7518\u8349\u3001\u9ec4\u82aa\u3001\u5f53\u5f52\u5728ILD\u7684\u6cbb\u7597\u4e2d\u8d77\u7740\u91cd\u8981\u4f5c\u7528\u3002\u7814\u7a76\u53d1\u73b0\uff0c\u901a\u8fc7\u7f13\u89e3\u708e\u75c7\u548c\u6c27\u5316\u5e94\u6fc0\u3001\u8c03\u8282\u514d\u75ab\u7cfb\u7edf\u3001\u4fc3\u8fdb\u7ec4\u7ec7\u4fee\u590d\u662fILD\u6cbb\u7597\u7684\u6709\u6548\u7b56\u7565\u3002<\/p>\n

\u53d1\u8868\u671f\u520a\uff1a<\/strong>J Ethnopharmacol. 2024 Jan 10;318(Pt A):116952.<\/p>\n

\u901a\u8baf\u4f5c\u8005\/\u5173\u952e\u4f5c\u8005\uff1a<\/strong>Yuan-Lu Cui \uff0cYan-Ming Zhou<\/p>\n

\u4e3b\u8981\u4f5c\u8005\u5355\u4f4d\uff1a<\/strong>\u5929\u6d25\u4e2d\u533b\u836f\u5927\u5b66\u7ec4\u5206\u4e2d\u836f\u56fd\u5bb6\u91cd\u70b9\u5b9e\u9a8c\u5ba4\uff1b\u5929\u6d25\u533b\u79d1\u5927\u5b66\u7b2c\u4e8c\u533b\u9662<\/p>\n

\u201409\u2014<\/strong><\/p>\n

Gastroenterology\uff1a\u4e8e\u541b\u6559\u6388\u56e2\u961f\u53d1\u73b0\u7247\u4ed4\u7640\u53ef\u9884\u9632\u7ed3\u76f4\u80a0\u764c\u7684\u53d1\u751f<\/strong><\/p>\n

doi: 10.1053\/j.gastro.2023.08.052.<\/p>\n

\u7247\u4ed4\u7640(PZH)\u662f\u4e00\u79cd\u6210\u719f\u7684\u4e2d\u836f\u65b9\u5242\uff0c\u56e0\u5176\u5bf9\u5305\u62ec\u764c\u75c7\u5728\u5185\u7684\u5404\u79cd\u708e\u75c7\u75be\u75c5\u7684\u6709\u76ca\u4f5c\u7528\u800c\u53d7\u5230\u5e7f\u6cdb\u5173\u6ce8\u3002\u7247\u4ed4\u7640\u4e3b\u8981\u7531\u9e9d\u9999\u3001\u725b\u9ec4\u3001\u86c7\u80c6\u548c\u4e09\u4e03\u6839\u7ec4\u6210\u3002<\/p>\n

\u6765\u81ea\u9999\u6e2f\u4e2d\u6587\u5927\u5b66\u4e8e\u541b\u6559\u6388\u56e2\u961f\u5728Gastroenterology\u4e0a\u53d1\u8868\u4e86\u4e00\u9879\u7814\u7a76\uff0c\u8be5\u7814\u7a76\u91c7\u7528\u4e86\u4e00\u79cd\u7cfb\u7edf\u7684\u65b9\u6cd5\u6765\u7814\u7a76\u7247\u4ed4\u7640-\u80a0\u9053\u5fae\u751f\u7269\u7fa4\u4e32\u6270\u5728\u9884\u9632\u7ed3\u76f4\u80a0\u764c\u4e2d\u7684\u4f5c\u7528\u3002\u8be5\u7814\u7a76\u53d1\u73b0\u7247\u4ed4\u7640\u901a\u8fc7\u4e30\u5bcc\u76ca\u751f\u83cc\u548c\u6709\u76ca\u4ee3\u8c22\u7269\u6765\u9006\u8f6c\u7ed3\u76f4\u80a0\u764c\u76f8\u5173\u7684\u80a0\u9053\u751f\u6001\u5931\u8c03\uff0c\u8fd9\u6709\u52a9\u4e8e\u6539\u5584\u80a0\u9053\u5c4f\u969c\u529f\u80fd\u548c\u6291\u5236\u81f4\u764c\u4fe1\u53f7\u7ea7\u8054\u53cd\u5e94\u3002\u540c\u65f6\uff0c\u7814\u7a76\u8005\u8fd8\u5c0f\u9f20\u4e2d\u68c0\u6d4b\u4e86\u7247\u4ed4\u7640\u5bf9\u7ed3\u76f4\u80a0\u764c\u7684\u5316\u5b66\u9884\u9632\u4f5c\u7528\u3002<\/p>\n

\u603b\u4e4b\uff0c\u8be5\u7814\u7a76\u7ed3\u679c\u8868\u660e\u7247\u4ed4\u7640\u662f\u7ed3\u76f4\u80a0\u764c\u4e2d\u4e00\u79cd\u6f5c\u5728\u7684\u5316\u5b66\u9884\u9632\u836f\u7269\uff0c\u5e76\u4e14\u5176\u4e0e\u80a0\u9053\u5fae\u751f\u7269\u7fa4\u7684\u76f8\u4e92\u4f5c\u7528\u662f\u5176\u6cbb\u7597\u53cd\u5e94\u7684\u5173\u952e\u56e0\u7d20\u3002<\/p>\n

\u53d1\u8868\u671f\u520a\uff1a<\/strong>Gastroenterology. 2023 Dec;165(6):1404-1419.<\/p>\n

\u901a\u8baf\u4f5c\u8005\/\u5173\u952e\u4f5c\u8005\uff1a<\/strong>Jun Yu\uff0c Xiaoxing Li<\/p>\n

\u4e3b\u8981\u4f5c\u8005\u5355\u4f4d\uff1a<\/strong>\u9999\u6e2f\u4e2d\u6587\u5927\u5b66\uff1b\u4e2d\u5c71\u5927\u5b66\u9644\u5c5e\u7b2c\u4e00\u533b\u9662\u7cbe\u51c6\u533b\u5b66\u7814\u7a76\u6240<\/p>\n

\u2014 10\u2014<\/strong><\/p>\n

Pharmacol Res\uff1a\u7fc1\u4e60\u751f\u6559\u6388\u56e2\u961f\u63ed\u793a\u9aa8\u901a\u8d34\u818fvs NSAIDs\u6cbb\u7597\u819d\u9aa8\u5173\u8282\u708e\u7684\u7597\u6548\u5dee\u5f02<\/strong><\/p>\n

doi: 10.1016\/j.phrs.2023.106954.<\/p>\n

\u9aa8\u5173\u8282\u708e\u662f\u4e00\u79cd\u5e38\u89c1\u7684\u9000\u884c\u6027\u5173\u8282\u75be\u75c5\u3002\u76ee\u524d\u63a8\u8350\u7684\u6cbb\u7597\u5305\u62ec\u57fa\u7840\u6cbb\u7597\u3001\u836f\u7269\u6cbb\u7597\u548c\u5916\u79d1\u6cbb\u7597\u3002\u4f20\u7edf\u4e2d\u6210\u836f\u8d34\u818f\u5242\u5982\u9aa8\u901a\u8d34\u818f\uff08GTP\uff09\u662f\u4e2d\u56fd\u5e38\u89c1\u7684\u7ecf\u76ae\u7ed9\u836f\u65b9\u6cd5\uff0c\u5177\u6709\u826f\u597d\u7684\u7597\u6548\u3001\u5b89\u5168\u6027\u548c\u4f9d\u4ece\u6027\u3002\u9aa8\u901a\u8d34\u818f\uff08GTP\uff09\u4f5c\u4e3a\u8001\u5b57\u724c\u7684\u4e2d\u836f\u8d34\u818f\u4e4b\u4e00\uff0c\u5176\u7597\u6548\u548c\u5b89\u5168\u6027\u5f97\u5230\u4e86\u4e34\u5e8a\u8ba4\u53ef\u548c\u4e00\u5b9a\u7684\u5faa\u8bc1\u652f\u6301\uff0c\u4f46\u76ee\u524d\u5c1a\u7f3a\u4e4fGTP\u4e0eNSAIDs\u5728OA\u6cbb\u7597\u4e2d\u5b89\u5168\u6027\u548c\u7597\u6548\u7684\u6bd4\u8f83\u3002<\/p>\n

\u6765\u81ea\u4e2d\u56fd\u533b\u5b66\u79d1\u5b66\u9662\u9aa8\u79d1\u7814\u7a76\u4e2d\u5fc3\u4e3b\u4efb\u3001\u5317\u4eac\u534f\u548c\u533b\u9662\u9aa8\u79d1\u4e3b\u4efb\u533b\u5e08\u3001\u535a\u58eb\u751f\u5bfc\u5e08\u3001\u5916\u79d1\u5b66\u7cfb\u4e3b\u4efb\u7fc1\u4e60\u751f\u6559\u6388\u7275\u5934\u5168\u56fd35\u4e2a\u533b\u5b66\u4e2d\u5fc3\u5b8c\u6210\u4e86\u9996\u4e2a\u4e2d\u6210\u836f\u8d34\u818f\u7684\u524d\u77bb\u6027\u771f\u5b9e\u4e16\u754c\u7814\u7a76\uff0c\u7cfb\u7edf\u9610\u8ff0\u4e86\u9aa8\u901a\u8d34\u818f\u548cNSAIDs\u6cbb\u7597\u819d\u9aa8\u5173\u8282\u708e\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u5dee\u5f02\u3002<\/p>\n

\u672c\u7814\u7a76\u8868\u660e\uff0c\u9aa8\u901a\u8d34\u818f\u6216NSAIDs\u5728\u51cf\u8f7b\u819d\u5173\u8282\u75bc\u75db\u548c\u6539\u5584\u60a3\u8005\u751f\u6d3b\u8d28\u91cf\u65b9\u9762\u5177\u6709\u826f\u597d\u6548\u679c\u3002\u9aa8\u901a\u8d34\u818f\u5355\u72ec\u4f7f\u7528\u5177\u6709\u826f\u597d\u7684\u80c3\u80a0\u9053\u8010\u53d7\u6027\uff0c\u5e76\u4e14\u63a5\u89e6\u6027\u76ae\u708e\u7684\u53d1\u751f\u7387\u8f83\u4f4e\u3002\u9aa8\u901a\u8d34\u818f\u548cNSAIDs\u6cbb\u7597\u819d\u9aa8\u5173\u8282\u708e\u7684\u6548\u679c\u76f8\u5f53\uff0c\u5747\u53ef\u4ee5\u5355\u72ec\u5e94\u7528\u3002\u7279\u522b\u662f\u5bf9\u4e8e\u8001\u5e74\u3001\u865a\u5f31\u3001\u6709\u5fc3\u8840\u7ba1\u548c\u80c3\u80a0\u9053\u5408\u5e76\u75c7\u7684\u60a3\u8005\uff0c\u9aa8\u901a\u8d34\u818f\u662f\u66f4\u597d\u7684\u9009\u62e9\u3002<\/p>\n

\u53d1\u8868\u671f\u520a\uff1a<\/strong>Pharmacol Res. 2023 Nov:197:106954.<\/p>\n

\u901a\u8baf\u4f5c\u8005\/\u5173\u952e\u4f5c\u8005\uff1a<\/strong>Xisheng Weng\uff0cYingjie Wang<\/p>\n

\u4e3b\u8981\u4f5c\u8005\u5355\u4f4d\uff1a<\/strong>\u5317\u4eac\u534f\u548c\u533b\u9662\uff1b\u4e2d\u56fd\u533b\u5b66\u79d1\u5b66\u9662\u9aa8\u79d1\u7814\u7a76\u4e2d\u5fc3<\/p>\n","protected":false},"excerpt":{"rendered":"

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