\u3000\u3000\u901a\u7edc\uff1a\u5fc3\u8111\u8840\u7ba1\u591a\u91cd\u4fdd\u62a4\u4f5c\u7528<\/strong><\/p>\n

\u3000\u3000\u5fc3\u8111\u8840\u7ba1\u75c5\u662f\u7531\u4e8e\u52a8\u8109\u7ca5\u6837\u786c\u5316\u548c\u8840\u6813\u5f62\u6210\u5f15\u8d77\u7684\u5fc3\u8111\u7ec4\u7ec7\u7f3a\u8840\u75c5\u53d8\uff0c\u5305\u62ec\u51a0\u5fc3\u75c5\u3001\u5fc3\u808c\u6897\u6b7b\u3001\u8111\u6897\u585e\u7b49\u3002\u901a\u5fc3\u7edc\u80f6\u56ca\u662f\u7edc\u75c5\u7406\u8bba\u6307\u5bfc\u4e0b\u6cbb\u7597\u5fc3\u8111\u8840\u7ba1\u75c5\u7684\u4ee3\u8868\u836f\u7269\uff0c\u5177\u6709\u8840\u6db2\u4fdd\u62a4\u3001\u8840\u7ba1\u4fdd\u62a4\u3001\u7f3a\u8840\u7ec4\u7ec7\u4fdd\u62a4\u4f5c\u7528\uff0c\u53ef\u4ee5\u4fdd\u62a4\u8840\u7ba1\u5185\u76ae\u7ec6\u80de\uff0c\u89e3\u9664\u8840\u7ba1\u75c9\u631b\uff0c\u7a33\u5b9a\u6613\u635f\u6591\u5757\uff0c\u51cf\u5c11\u5fc3\u808c\u7f3a\u8840\/\u518d\u704c\u6ce8\u635f\u4f24\u7b49\u3002\u7f8e\u3001\u82f1\u591a\u5bb6\u56fd\u5916\u533b\u5b66\u6742\u5fd7\u90fd\u6536\u5165\u4e86\u5173\u4e8e\u901a\u5fc3\u7edc\u591a\u91cd\u5fc3\u8111\u4fdd\u62a4\u4f5c\u7528\u7684\u8bba\u6587\u3002<\/p>\n

\u3000\u3000\u82f1\u56fd\u300a\u6c11\u65cf\u836f\u7406\u5b66\u6742\u5fd7\u300b\u520a\u53d1\u300aPI-3K\/Akt\/HIF\/eNOS\u4fe1\u53f7\u901a\u8def\u5728\u4e2d\u836f\u901a\u5fc3\u7edc\u6539\u5584\u8840\u7ba1\u5185\u76ae\u529f\u80fd\u4e2d\u7684\u4f5c\u7528\u300b\u8bba\u6587\u8bc1\u5b9e\uff0c\u901a\u5fc3\u7edc\u53ef\u901a\u8fc7PI-3K\/Akt\/HIF\u4f9d\u8d56\u7684\u4fe1\u53f7\u901a\u8def\u4e0a\u8c03eNOS\u8868\u8fbe\uff0c\u8fdb\u800c\u6539\u5584\u8840\u7ba1\u5185\u76ae\u4f9d\u8d56\u6027\u8840\u7ba1\u8212\u5f20\u529f\u80fd\uff0c\u4fdd\u62a4\u8840\u7ba1\u5185\u76ae;\u5176\u520a\u53d1\u7684\u53e6\u4e00\u7bc7\u8bba\u6587\u300a\u4e2d\u836f\u901a\u5fc3\u7edc\u663e\u8457\u964d\u4f4e\u5154\u8840\u8102\u6c34\u5e73\u7a33\u5b9a\u6613\u635f\u6591\u5757\u300b\uff0c\u7531\u4e2d\u56fd\u533b\u79d1\u5927\u5b66\u66fe\u5b9a\u5c39\u6559\u6388\u3001\u8c22\u83b2\u5a1c\u535a\u58eb\u5b8c\u6210\uff0c\u7814\u7a76\u8868\u660e\uff1a\u901a\u5fc3\u7edc\u6709\u6548\u7f13\u89e3\u8840\u7ba1\u75c9\u631b\uff0c\u6539\u5584\u9888\u52a8\u8109\u8840\u6d41\u91cf\u53ca\u8840\u7ba1\u5bf95-\u7f9f\u8272\u80fa\u7684\u9ad8\u654f\u611f\u6027\uff0c\u6709\u6548\u6cbb\u7597\u51a0\u5fc3\u75c5\u5fc3\u7ede\u75db\uff0c\u5176\u673a\u5236\u4e0e\u6291\u5236RhoA\/Rho\u6fc0\u9176\u9014\u5f84\u6709\u5173\u3002<\/p>\n

\u3000\u3000\u82f1\u56fd\u300aBMC \u8865\u5145\u548c\u66ff\u4ee3\u533b\u5b66\u300b\u520a\u767b\u7684\u4ee5\u5cad\u533b\u836f\u7814\u7a76\u9662\u4e0e\u7f8e\u56fd\u8d1d\u52d2\u533b\u5b66\u9662\u5408\u4f5c\u627f\u62c5\u7684\u56fd\u9645\u79d1\u6280\u5408\u4f5c\u9879\u76ee\u7814\u7a76\u8bba\u6587\u300a\u590d\u65b9\u4e2d\u836f\u63d0\u53d6\u7269(\u901a\u5fc3\u7edc)\u5bf9\u6e38\u79bb\u8102\u80aa\u9178\u8bf1\u5bfc\u5185\u76ae\u635f\u4f24\u7684\u4fdd\u62a4\u4f5c\u7528\uff1a\u6297\u6c27\u5316\u7cfb\u7edf\u7684\u610f\u4e49\u300b\u8868\u660e\uff0c\u901a\u5fc3\u7edc\u53ef\u4f7f\u8f6f\u8102\u9178\u8bf1\u5bfc\u7684\u8840\u7ba1\u5185\u76ae\u7ec6\u80de\u51cb\u4ea1\u7387\u7531\u6a21\u578b\u7ec473%\u964d\u4f4e\u81f37%\uff0c\u5176\u673a\u5236\u4e0e\u8be5\u836f\u901a\u8fc7\u6fc0\u6d3bAMPK\u901a\u8def\u542f\u52a8\u4fdd\u62a4\u673a\u5236\uff0c\u589e\u5f3a\u786b\u6c27\u8fd8\u86cb\u767d\u6297\u6c27\u5316\u7cfb\u7edf\uff0c\u964d\u4f4e\u786b\u6c27\u8fd8\u539f\u4ea4\u4e92\u4f5c\u7528\u86cb\u767d\u8868\u8fbe\uff0c\u540c\u65f6\u6291\u5236MAPK\u901a\u8def\u51cf\u5c11\u635f\u4f24\u56e0\u7d20\uff0c\u964d\u4f4e\u6d3b\u6027\u6c27\u8868\u8fbe\u6709\u5173\u3002#p#\u526f\u6807\u9898#e#<\/p>\n

\u3000\u3000\u300a\u7f8e\u56fd\u751f\u7406\u5b66\u6742\u5fd7\u300b\u662f\u4e16\u754c\u6743\u5a01\u533b\u5b66\u6742\u5fd7\uff0c\u7531\u5c71\u4e1c\u5927\u5b66\u9f50\u9c81\u533b\u9662\u5f20\u8fd0\u9662\u58eb\u3001\u5f20\u857e\u535a\u58eb\u5b8c\u6210\u7684\u300a\u901a\u5fc3\u7edc\u5242\u91cf\u4f9d\u8d56\u6027\u589e\u5f3a\u6613\u635f\u6591\u5757\u7a33\u5b9a\u6027\uff1a\u4e0e\u5927\u5242\u91cf\u8f9b\u4f10\u4ed6\u6c40\u6bd4\u8f83\u300b\u7814\u7a76\u8bc1\u5b9e\uff1a\u9ad8\u3001\u4e2d\u5242\u91cf\u901a\u5fc3\u7edc\u80f6\u56ca\u5728\u964d\u4f4e\u6613\u635f\u6591\u5757\u7834\u88c2\u7387\u65b9\u9762\u4e0e\u897f\u836f\u8f9b\u4f10\u4ed6\u6c40\u4f5c\u7528\u76f8\u5f53\uff0c\u5e76\u4ece\u8c03\u8102\u3001\u6297\u708e\u3001\u6297\u6c27\u5316\u7b49\u65b9\u9762\u9610\u660e\u901a\u5fc3\u7edc\u7a33\u5b9a\u6613\u635f\u6591\u5757\u7684\u4f5c\u7528\u673a\u5236\u3002\u8be5\u9879\u7814\u7a76\u53d1\u8868\u5728\u300a\u7f8e\u56fd\u751f\u7406\u5b66\u6742\u5fd7\u00b7\u5fc3\u810f\u5faa\u73af\u751f\u7406\u300b(SCI\u8bba\u6587\u5f71\u54cd\u56e0\u5b50\uff1a3.6)\uff0c\u7f16\u8f91\u90e8\u914d\u53d1\u4e13\u9898\u8bc4\u8bba\u9898\u76ee\u4e3a\u300a\u4f20\u7edf\u4e2d\u533b\u836f\u5bf9\u73b0\u4ee3\u533b\u5b66\u7684\u6311\u6218\u300b\uff0c\u8bc4\u8bba\u4e2d\u79f0\uff1a\u201c\u672c\u7814\u7a76\u4e3a\u672a\u6765\u53ef\u80fd\u53d1\u5c55\u6210\u51a0\u5fc3\u75c5\u4e8b\u4ef6\u7684\u9ad8\u5371\u60a3\u8005\u70b9\u71c3\u4e86\u5e0c\u671b\u4e4b\u706f\u2026\u2026\u901a\u5fc3\u7edc\u5728\u6b64\u9886\u57df\u4e2d\u5177\u6709\u6f5c\u5728\u7684\u4e34\u5e8a\u4ef7\u503c\uff0c\u6709\u671b\u6210\u4e3a\u4e00\u4e2a\u6591\u5757\u7a33\u5b9a\u5242\u201d\uff0c\u5bf9\u4e8e\u672c\u9879\u7814\u7a76\u7ed9\u4e88\u4e86\u9ad8\u5ea6\u8bc4\u4ef7\u3002<\/p>\n

\u3000\u30002010\u5e74\u7531\u5317\u4eac\u961c\u5916\u5fc3\u8840\u7ba1\u75c5\u533b\u9662\u6768\u8dc3\u8fdb\u6559\u6388\u3001\u674e\u5411\u4e1c\u535a\u58eb\u5b8c\u6210\u7684\u300a\u901a\u5fc3\u7edc\u901a\u8fc7PKA\u901a\u8def\u6fc0\u6d3beNOS\u78f7\u9178\u5316\u51cf\u5c11\u5fc3\u808c\u65e0\u590d\u6d41\u548c\u5fc3\u808c\u6897\u6b7b\u518d\u704c\u6ce8\u635f\u4f24\u300b\uff0c\u4ece\u4fe1\u53f7\u901a\u8def\u89d2\u5ea6\u6df1\u5165\u63ed\u793a\u4e86\u901a\u5fc3\u7edc\u80f6\u56ca\u51cf\u5c11\u5fc3\u808c\u65e0\u518d\u6d41\u548c\u5fc3\u6897\u540e\u518d\u704c\u6ce8\u635f\u4f24\u7684\u91cd\u8981\u673a\u5236\uff0c\u8fd9\u9879\u7814\u7a76\u4e5f\u520a\u767b\u5728\u300a\u7f8e\u56fd\u751f\u7406\u5b66\u6742\u5fd7\u00b7\u5fc3\u810f\u5faa\u73af\u751f\u7406\u300b\u4e0a\uff0c\u5f15\u8d77\u56fd\u5916\u533b\u5b66\u754c\u7684\u5173\u6ce8\uff0c\u7f8e\u56fd\u52a0\u5229\u798f\u5c3c\u4e9a\u5927\u5b66John Longhurst\u6559\u6388\u7279\u9080\u4e3b\u7814\u4eba\u5458\u5c31\u901a\u5fc3\u7edc\u7814\u7a76\u8d74\u7f8e\u5f00\u5c55\u5b66\u672f\u4ea4\u6d41\u3002<\/p>\n

\u3000\u3000\u5b66\u672f\u4ea4\u6d41\u4f1a\u4e0a\u5434\u4ee5\u5cad\u6559\u6388\u4e0eJohn Longhurst\u6559\u6388\u5c31\u901a\u5fc3\u7edc\u7814\u53d1\u5386\u7a0b\u3001\u901a\u5fc3\u7edc\u5728\u5fc3\u8111\u8840\u7ba1\u75be\u75c5\u9632\u6cbb\u65b9\u9762\u7684\u6700\u65b0\u8fdb\u5c55\u5f00\u5c55\u7814\u8ba8\uff0c\u5f20\u8fd0\u9662\u58eb\u4e0e\u6768\u8dc3\u8fdb\u6559\u6388\u5206\u522b\u5c31\u901a\u5fc3\u7edc\u5bf9\u52a8\u8109\u7ca5\u6837\u786c\u5316\u6613\u635f\u6591\u5757\u7814\u7a76\u3001\u901a\u5fc3\u7edc\u6cbb\u7597\u6025\u6027\u5fc3\u6897\u65e0\u518d\u6d41\u7814\u7a76\u4f5c\u4e3b\u9898\u62a5\u544a\uff0c\u4f7f\u56fd\u5916\u4e13\u5bb6\u4e86\u89e3\u5230\u4f20\u7edf\u4e2d\u533b\u836f\u5728\u76ee\u524d\u897f\u533b\u5b66\u4e34\u5e8a\u68d8\u624b\u96be\u9898\u65b9\u9762\u7684\u8fdb\u5c55\u3002<\/p>\n

\u3000\u3000\u5728\u7b2c\u516b\u5c4a\u56fd\u9645\u7edc\u75c5\u5b66\u5927\u4f1a\u4e0a\uff0c\u7f8e\u56fd\u52a0\u5229\u798f\u5c3c\u4e9a\u5927\u5b66John Longhurst\u6559\u6388\u7279\u610f\u6765\u5230\u4e2d\u56fd\u53c2\u4f1a\u3002<\/p>\n

\u3000\u3000\u6811\u7a81\u72b6\u7ec6\u80de\u5728\u8bf1\u5bfc\u548c\u8c03\u8282\u514d\u75ab\u5e94\u7b54\u4e2d\u53d1\u6325\u7740\u5173\u952e\u4f5c\u7528\uff0c\u6210\u719f\u7684\u6811\u7a81\u72b6\u7ec6\u80de\u53c2\u4e0e\u52a8\u8109\u7ca5\u6837\u786c\u5316\u7684\u5f62\u6210\u673a\u5236\uff0c\u7531\u845b\u5747\u6ce2\u9662\u58eb\u3001\u82cf\u851a\u535a\u58eb\u5b8c\u6210\u7684\u300a\u901a\u5fc3\u7edc\u62bd\u63d0\u7269\u963b\u65ad\u6c27\u5316\u578b\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u8bf1\u5bfc\u7684\u4eba\u5355\u6838\u7ec6\u80de\u6765\u6e90\u6811\u7a81\u72b6\u7ec6\u80de\u7684\u514d\u75ab\u6210\u719f\u7684\u7814\u7a76\u300b\u8bc1\u5b9e\uff0c\u901a\u5fc3\u7edc\u6291\u5236\u6c27\u5316\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u8bf1\u5bfc\u7684\u6811\u7a81\u72b6\u7ec6\u80de\u5206\u5316\u548c\u6210\u719f\uff0c\u589e\u5f3a\u5171\u523a\u6fc0\u5206\u5b50\u53ca\u5206\u6ccc\u7ec6\u80de\u56e0\u5b50\u7684\u6d3b\u6027\uff0c\u51cf\u5f31\u5176\u541e\u566c\u80fd\u529b\uff0c\u4ece\u800c\u8c03\u8282\u52a8\u8109\u7ca5\u6837\u786c\u5316\u75c5\u53d8\u4e2d\u7684\u708e\u75c7\u53ca\u514d\u75ab\u53cd\u5e94\uff0c\u5ef6\u7f13\u52a8\u8109\u7ca5\u6837\u786c\u5316\u8fdb\u7a0b\uff0c\u51cf\u5c11\u6025\u6027\u5fc3\u8111\u8840\u7ba1\u4e8b\u4ef6\u7684\u53d1\u751f\uff0c\u8fd9\u4e00\u7814\u7a76\u4e5f\u520a\u767b\u5728\u7f8e\u56fd\u300a\u5fc3\u8840\u7ba1\u836f\u7406\u6742\u5fd7\u300b\u4e0a\u3002<\/p>\n

\u3000\u3000\u5728\u6709\u6548\u6cbb\u7597\u6025\u6027\u5fc3\u6897\u65b9\u9762\uff0c\u7531\u6768\u8dc3\u8fdb\u6559\u6388\u3001\u94b1\u6d77\u71d5\u535a\u58eb\u5b8c\u6210\u7684\u7814\u7a76\u8868\u660e\uff0c\u901a\u5fc3\u7edc\u6539\u5584\u6897\u6b7b\u5fc3\u808c\u5c40\u90e8\u5fae\u73af\u5883\uff0c\u6709\u5229\u4e8e\u79fb\u690d\u7ec6\u80de\u7684\u5b58\u6d3b\u548c\u5206\u5316\uff0c\u589e\u52a0\u5fc3\u810f\u5de6\u5ba4\u5c04\u8840\u5206\u6570\uff0c\u51cf\u5c11\u5ba4\u58c1\u8fd0\u52a8\u969c\u788d\u8282\u6bb5\u6570\u548c\u5de6\u5ba4\u8d28\u91cf\u6307\u6570\uff0c\u7f29\u5c0f\u6897\u6b7b\u9762\u79ef\u3002\u8fdb\u4e00\u6b65\u7814\u7a76\u8bc1\u5b9e\u5176\u4e0e\u51cf\u5c11\u5fc3\u808c\u7ec6\u80de\u51cb\u4ea1\uff0c\u51cf\u8f7b\u81ea\u7531\u57fa\u635f\u4f24\uff0c\u6291\u5236\u708e\u75c7\u53cd\u5e94\u7b49\u673a\u5236\u6709\u5173\u3002<\/p>\n

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